After this regulation, Kaisermühlen suddenly found itself on the left bank of the Danube. Naturally, the ship mills could no longer be operated on the “Old Danube”, which was now at a standstill. Due to the Industrial Revolution, however, they had become increasingly irrelevant anyway and soon disappeared completely from the landscape. The steamboat station, which had only been built a few decades earlier, had to be relocated to the bank of the new main river on the city side, which meant that the many restaurateurs and carters in Kaisermühlen lost their source of income. As a result, the area was built up in a grid pattern with “Zinskasernen” (low-standard apartment buildings) and some areas fell into the hands of industrial companies.
Around the turn of the century, a streetcar ran across Wagramer Straße and Reichsbrücke for the first time, which meant that the outskirts of Kaisermühlen were connected to public transport for the first time.
During the war, Kaisermühlen, with its many newly built large municipal buildings, was one of the most important sites of the February battles in 1934. After the annexation in 1938, the district was transferred to the 21st district, Floridsdorf, in the new Greater Vienna. It was not until 1954 that Kaisermühlen, together with seven other former municipalities, formed the 22nd district of Donaustadt.
Around half a century later, the Kaisermühlen subway station was opened on Wagramer Straße.